01 - Whisk buttermilk and hot sauce in a large bowl. Submerge chicken pieces completely, cover, and refrigerate for 1 hour minimum or overnight for optimal flavor penetration.
02 - Combine paprika, garlic powder, onion powder, oregano, thyme, cayenne pepper, black pepper, and salt in a small bowl. Measure 2 teaspoons for breading mixture.
03 - Mix flour, cornstarch, and reserved 2 teaspoons Cajun seasoning in a shallow dish until evenly distributed.
04 - Remove chicken from marinade, allowing excess liquid to drip off. Press each piece firmly into flour mixture, ensuring complete coverage on all sides.
05 - Pour vegetable oil 2 inches deep in a large skillet or Dutch oven. Heat to 350°F maintaining consistent temperature throughout cooking.
06 - Cook chicken in batches without overcrowding. Turn pieces occasionally until golden brown and internal temperature reaches 165°F, approximately 12-15 minutes per batch.
07 - Transfer fried chicken to wire rack or paper towels to drain. Allow to rest for 5 minutes before serving to retain juiciness.